Pharmacological studies on 8-[(1,4-benzodioxan-2-yl) methyl]-3-oxo-1-thia-4,8-diazaspiro-[4,5]-decane maleate.
نویسندگان
چکیده
Studies have been so far made on the benzodioxane derivatives as a cardiovascular drug which were reported as a peripheral vasodilator, or as a hypotensive agent by Schaper et al. (1) and Green et al. (2). 8-[(1, 4-benzodioxan-2-yl) methyl]-3-oxo-l-thia-4, 8-dia zaspiro-[4, 5]-decane maleate (Y-3506) was found desirable as a peripheral vasodilator with low toxicity among the new derivatives synthesized by this laboratory. This report deals with the effects of Y-3506 on the cardiovascular system of the experimental animals in comparison with those of several known vasodilators as reference compounds.
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ورودعنوان ژورنال:
- Japanese journal of pharmacology
دوره 21 3 شماره
صفحات -
تاریخ انتشار 1971